the protective effect of medicinal herbs extracts including cynara scolymus l., cichorium intybus l. taraxacum officinal l. and berberis vulgaris l. in single and in combination form in ccl4 induced rat liver toxicity

نویسندگان

h fallah huseini department of biochemistry, baquiatallah university of medical sciences, tehran, tel & fax: +98-21-22289941

a zaree mahmoudabady department of biochemistry, baquiatallah university of medical sciences

h naghdi badi department of cultivation and development, institute of medicinal plants acecr

s.m. alavian department of pharmacology and applied medicine, institute of medicinal plants acecr

چکیده

background: several herbal remedies are used in traditional medicine for treatment of liver disorders, but their efficacy, safety, and dosage have not been investigated so far. objective: the present study was aimed to evaluate the liver protective effects of medicinal herbs extracts such as cynara scolymus leave (artichok), cichorium intybus roots (chichory), taraxacum officinale root (dandelium), berberis vulgaris (barberry) root and stems extract in single and in combination form against carbon tetrachloride (ccl4) induced liver toxicity. methods: total 70 wistar male rat, aged 5 months were divided in 7 groups of 10 rats each. one group kept as normal and out of six ccl4 intoxicated groups one served as control, one received mixture of four extract and four groups received artichok, chichory, dandelium, and barberry in the dosage of 150, 300, 300 and 250 mg/kg/day respectively. the plant extracts were injected intra peritoneal simultaneously with intoxication for three days. three days after intoxication and extract treatments the serum liver enzymes levels such as alt, ast and alp as well as serum gluthathion and catalase were determined. results: in group receiving mixture of 4 herbal extract the blood level of alt, ast and alp were reduced significantly as compared to control group. in all the groups receiving herbal extracts the serum glutathione and catalase levels did not differ as compared to control groups. conclusion: in the present study administration of chichory, artichoke, dandelium and barberry in combination form prevent liver intoxication withought influence on serum antioxidant properties.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Protective Effect of Medicinal Herbs Extracts Including Cynara scolymus L., Cichorium intybus L. Taraxacum officinal L. and Berberis vulgaris L. in Single and in Combination Form in CCl4 Induced Rat Liver Toxicity

Background: Several herbal remedies are used in traditional medicine for treatment of liver disorders, but their efficacy, safety, and dosage have not been investigated so far. Objective: The present study was aimed to evaluate the liver protective effects of medicinal herbs extracts such as Cynara scolymus leave (artichok), Cichorium intybus roots (chichory), Taraxacum officinale root (dande...

متن کامل

The Effects of Taraxacum officinale L. and Berberis vulgaris L. Root Extracts on Carbon Tetrachloride Induced Liver Toxicity in Rats

  Background: Taraxacum officinale and Berberis vulgaris have long been used as herbal remedies for treatment of a variety of complaints including liver dysfunction and gallbladder disease. However scientifically reliable data are needed to verify their minimum effective doses.   Objective: In present study, the effects of Taraxacum officinale L. and Berberis vulgaris L. root extracts at the di...

متن کامل

The Effects of Cynara scolymus L. Leaf and Cichorium intybus L. Root Extracts on Carbon Tetrachloride Induced Liver Toxicity in Rats

Background: Cynara scolymus and Cichorium intybus are popular herbal remedy in folk medicine for liver disorders. Although many experimental studies carried out, scientifically reliable data needed to verify minimum effective dosage and efficacy of these medicinal plants. Objective: In present investigation, the effects of C. scolymus leaf and C. intybus root extracts at different doses were t...

متن کامل

the effects of cynara scolymus l. leaf and cichorium intybus l. root extracts on carbon tetrachloride induced liver toxicity in rats

background: cynara scolymus and cichorium intybus are popular herbal remedy in folk medicine for liver disorders. although many experimental studies carried out, scientifically reliable data needed to verify minimum effective dosage and efficacy of these medicinal plants. objective: in present investigation, the effects of c. scolymus leaf and c. intybus root extracts at different doses were te...

متن کامل

Antioxidant and protective effect of hydroalcoholic extract of Celtis australis L. on CCL4 induced liver toxicity

Several human diseases including, cancer, rheumatoid arthritis, neurodegenerative and hepatic diseases are related to destructive effect of reactive oxygen species (ROS). Antioxidants may provide a possible solution to this problem.This study was carried out to investigate the effect of hydroalcoholic extract of Celtis australis on CCl4 induced hepatotoxicity in mice.  The antioxidant activity...

متن کامل

Preventive Effect of Cichorium Intybus L. Two Extracts on Cerulein-induced Acute Pancreatitis in Mice

OBJECTIVES Acute pancreatitis is an inflammatory condition of pancreas with sudden onset, high mortality rate and multiple organ failure characteristics. It has been shown that oxygen free radicals have an important role in development of pancreatitis and its complications. Antioxidant, anti-inflammatory, anti-hepatotoxicity and gastroprotective properties of Cichorium intybus L. suggest that t...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
فصلنامه علمی پژوهشی گیاهان دارویی

جلد ۱، شماره ۴۱، صفحات ۷۸-۸۵

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023